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KMID : 1161420170200121141
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Journal of Medicinal Food
2017 Volume.20 No. 12 p.1141 ~ p.1151
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Alzheimer's Disease-Current Status and Future Directions
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Bhardwaj Deepshikha
Mitra Connie
Narasimhulu Chandrakala Aluganti
Riad Aladdin
Doomra Mitsushita
Parthasarathy Sampath
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Abstract
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Alzheimer's disease (AD) is an age-related neurodegenerative disorder of the brain. The presence of amyloid-beta (Aβ) plaques, neurofibrillary tangles (NFTs), loss of neurons, synapses, and altered sensory perceptions, including memory loss, delineate AD. However, the cause of AD is not clearly known. Several genetic and nongenetic factors have been implicated in the disease. Of the genes, the ?4 allele of apolipoprotein E is the largest known genetic risk factor of AD. This review article focuses on the various genetic and other predisposing factors that account for AD, pathophysiology of the disease, and the mechanisms by which Aβ plaques and NFTs are formed and could affect AD brain. In addition, recent advances and current diagnostics available for AD patients are detailed. As oxidative stress has been implicated in the etiology of the disease, special emphasis is given for nutrition based antioxidant therapies and interventional strategies for reducing/treating AD.
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KEYWORD
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amyloid-beta plaques, amyloid precursor protein, apolipoprotein E, neurofibrillary tangles, neuroimaging, nutrition
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